Factorial design

A section on Factorial designs of randomised trials has been added to the ‘Study methods’    section of the Research Skills chapter.

Ascertainment bias

Ascertainment bias has been added to the  ‘Analysis of the Medical literature’ section of the Research Skills chapter.

CT head scan

Indications, tips on how to read head CTs and related CNS anatomy images have been included as new pages in the ‘Neurological assessment’ section of the Neurology Chapter.

Hyperosmolar therapy of raised ICP

Updated sections on ‘Prevention of secondary brain injury’ and Resusciation fluids’ following the latest review of hyper osmolar therapy published recently in the NEJM.

tPA in stroke

The section on Thrombolysis in stroke has been updated following release of the IST3 trial and accompanying meta-analysis of tPA for the treatment of stroke that casts doubts over the efficacy of tPA after 3 hours.