Subsegmental PE

Additional information about the management of isolated subsegmental PE has been added to the Management of PE page. Kearon, C, Akl, EA, Ornelas, J, et al. Antithrombotic therapy for vte disease: Chest guideline. Chest 2016 .

Clinical assessment of suspected ACS

The Clinical assessment of ACS page has been updated with revised information regarding LRs for ACS from the following article. Fanaroff, AC, Rymer, JA, Goldstein, SA, et al. Does This Patient With Chest Pain Have Acute Coronary Syndrome?: The Rational Clinical Examination Systematic Review. JAMA 2015;314(18):1955-65. http://www.ncbi.nlm.nih.gov/pubmed/26547467.

ANZ Cardiac Society hsTroponin guidelines

Some additional information about the Australian and New Zealand Cardiac Society 2011 guidelines on hsTroponin has been added to the Troponins in ACS page. 2011 addendum to the National Heart Foundation of Australia/Cardiac Society of Australia and New Zealand guidelines for the management of acute coronary syndromes (ACS) 2006. Heart, Lung and Circulation 2011;20(8):487-502.

hsTnT in renal impairment

Some additional information about hsTnT in patients with renal impairment (90% with eGFR 30-60mL/min) has been added to the Troponins in ACS page, derived from the following reference. Twerenbold, R, Wildi, K, Jaeger, C, et al. Optimal Cutoff Levels of More Sensitive Cardiac Troponin Assays for the Early Diagnosis of Myocardial Infarction in Patients With … Read more

D dimer in pregnancy

The PE in special populations page has been updated with particular reference to d dimer levels during pregnancy. Some relevant references are: Greer, IA. Pregnancy Complicated by Venous Thrombosis. New England Journal of Medicine 2015;373(6):540-47. http://www.nejm.org/doi/full/10.1056/NEJMcp1407434. Kline, JA, Williams, GW, Hernandez-Nino, J. D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed. Clin Chem 2005;51(5):825-9. … Read more