Dunn RJ
The Paracetamol page has been updated with information about the utility of a 2-4 hour paracetamol level in predicting subsequent potential toxicity. Yarema, MC, Green, JP, Sivilotti, MLA, et al. Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? Clinical Toxicology 2016:1-7.
The Calcium channel antagonists page has been revised following the publication of the following article. St-Onge, M, Anseeuw, K, Cantrell, FL, et al. Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults. Critical Care Medicine 2016.
The Ethanol page has been updated with some additional information about Wernicke’s encephalopathy.
The Paracetamol ingestion algorithm on the Paracetamol page has been updated with the expanded indications for oral activated charcoal contained in the September 2015 Australian management guidelines.
Some minor revisions to the Paracetamol page have been made, including the NNT (7) for charcoal within 2 hours of ingestion.
Some additional information about buprenorphine has been added to the Opioid antagonists & partial antagonists page.
The Illicit drug use page has been revised including a better description of the differences between drug tolerance, dependence and addiction.
Additional information about the management of opioid withdrawal in patients on medication assisted treatment for opioid dependence (MATOD) has been added to the Opioid antagonists & partial antagonists page.
The Opioid antagonist and partial agonists page has been updated with information about the recent decision to make naloxone available without prescription in Australia.
The Ethanol page has been updated with information about the rarity of thiamine deficiency in the Australian population after thiamine supplementation of flour was introduced in 1991.
Some additional details about the (mostly red discolouration) adverse effects of hydroxycobalamin has been added to the Cyanide page.
The Cyanide page has been updated to correct the statement that cyanide causes a non-anion gap acidosis -it causes an anion gap acidosis as stated elsewhere on the page.
A short segment on NBMOes has been added to the Other drugs of abuse page.
The management of supratherapeutic paracetamol ingestion has been revised on the Paracetamol page.
Recommendations from the latest Australian and New Zealand paracetamol management guidelines have been added to the Paracetamol page.
Some information about the usefulness of J-T interval prolongation as a marker of K channel blockade in patients with QRS prolongation has been added to the Electrocardiography and other relevant pages.
A CT demonstrating severe oesophageal injury following strong acid ingestion has been added to the Corrosives page.
A CXR following strong acid ingestion has been added to the Corrosives page.
An ECG demonstrating TCAD toxicity has been added to the Antidepressant toxicity page.
The Organophosphates page has been updated with additional information regarding PPE and therapy with atropine and pralidoxime iodide.