True vs false labour

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A table outlining the difference in the nature of contractions between true and false labour has been added to the Labour section.

Immature platelet fraction

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Information about the immature platelet fraction and how it can help differentiate causes of thrombocytopenia has been added to the Thrombocytopenia section.

6 new images uploaded

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New images of Biliary anatomy (Biliary disease), branches of the facial nerve (Assessment of facial weakness), differentiating pneumonia, PE and LVF (Assessment of CAP), auscultation sites for cardiac arrhythmias, cross sectional anatomy of the thigh (Penetrating limb trauma) have been uploaded. An updated image that better demonstrates the key functional cortical areas of the brain … Read more

Codeine metabolism

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Updated information regarding variations in metabolism of codeine in the Opioid Toxicity section of the Toxicology chapter.

IABP in cardiogenic shock

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Updated sections with new evidence from an RCT of IABP published recently in Journal of Intensive Care Medicine that did not show any overall mortality benefit from IABP. Patients < 50 years of age did have better outcomes however the power of the study was inadequate to indicate if this is a real difference.

Factorial design

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A section on Factorial designs of randomised trials has been added to the ‘Study methods’    section of the Research Skills chapter.

Ascertainment bias

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Ascertainment bias has been added to the  ‘Analysis of the Medical literature’ section of the Research Skills chapter.

CT head scan

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Indications, tips on how to read head CTs and related CNS anatomy images have been included as new pages in the ‘Neurological assessment’ section of the Neurology Chapter.

Hyperosmolar therapy of raised ICP

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Updated sections on ‘Prevention of secondary brain injury’ and Resusciation fluids’ following the latest review of hyper osmolar therapy published recently in the NEJM.

tPA in stroke

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The section on Thrombolysis in stroke has been updated following release of the IST3 trial and accompanying meta-analysis of tPA for the treatment of stroke that casts doubts over the efficacy of tPA after 3 hours.