Haematology

A new section better outlining the choice of anti-coagulants in DVT has been added to the Management of DVT page.

More changes have been made to the Other anticoagulants page, including an upgrading of rivaroxaban or apixaban to the preferred anti-coagulants for non valvular AF and VTE treatment.

More detail regarding potential drug interaction with NOACs has been added to the Other anticoagulants page.

A table outlining the different pharmacology of the most common NOACs has been added to the Other anticoagulants page.

A table outlining the different methods of monitoring NOAC therapy has been added to the Other anticoagulants page.

Some additional information about the dosing and efficacy of adnexanet in the reversal of anti-coagulation by NOACs has been added to the Reversal of anti-coagulation page.

The Other anticoagulants page has been updated with additional information on rivaroxaban and apixaban dosing.

Some additional information about Edoxaban has been added to the Other anticoagulants page (although it is not licensed in Australia and does not appear to have any advantage over rivaroxaban or apixaban), as well as a variety of small changes to information about the other NOACs. A good recent open access review article on the subject … Read more

The Deep venous thrombosis and Management of PE pages have been updated with some additional information about the home treatment of PE.

The Deep venous thrombosis page has been updated with more information about the utility of age adjusted d dimer for VTE. The use of an age adjusted cut off can safely reduce imaging by 20% in patients > 75 years of age.  (link)

Additional information about the predictive value of very high D dimer levels has been added to the Deep venous thrombosis page.

Additional information about Ferritin levels for the diagnosis of iron deficiency anaemia has been added to the Microcytic anaemia page.

Information about the direct anti-coagulant reversal agent PER 977 has been added to the Reversal of anti-coagulation page.

The Microcytic anaemia page has been updated with information about ferric carboxymaltose.

The Bone tumours page has been updated with additional information about osteolytic and osteosclerotic metastases.

A short section about Factor Eight Inhibitor Bypass Activity (FEIBA) has been added to the Clotting factor replacement page.

A small section with details of Fibrinogen concentrate (yes it actually is available in Australasia – sort of!) has been added to the Clotting factor replacement page.