Ketamine for seizure control
Ketamine has been added as a possible third line agent for seizure control to the Status epilepticus page, although evidence of efficacy for most other third line agents is higher.
Neurology
Intravenous aspirin
The Stroke management page has been updated with new information about IV aspirin
Phrase ‘benign intracranial hypertension’ removed
The phrase ‘benign intracranial hypertension’ has been removed from the manual – as idiopathic (venous) intracranial hypertension may not be clinically benign.
Idiopathic intracranial hypertension
The Idiopathic intracranial hypertension page has been updated – including venous sinus stenosis as the primary cause.
GBS
The Guillain Barre syndrome page has been revised and updated.
Clonus
The Peripheral nervous system examination page has been updated with some additional information about Clonus.
Sensitivity of CT for SAH
The Investigation of SAH page has been updated with revised sensitivities of CT for SAH.
Parkinson’s disease
The Parkinson’s disease page has had a number of other updates.
NMS differential diagnoses
The Neuroleptic malignant syndrome page has been updated with additional information about its differential diagnoses.
NMS treatment
The Neuroleptic malignant syndrome page has been updated with additional information about its treatment.
NMS complications
The Neuroleptic malignant syndrome page has been updated with additional information about its complications.
Neuroleptic malignant syndrome natural history
The Neuroleptic malignant syndrome page has been updated with additional information about its natural history.
Emergency aspects of Parkinson’s disease
The Parkinson’s disease page has been updated and a segment on the emergency aspects has been added.
Complications of SAH
The Subarachnoid haemorrhage page has been updated with additional information about complications.
Andexanet for ICH in patients on DOACs
The Management of stroke page has been updated with some information about andexanet for the treatment of ICH in patients taking DOACs – there is insufficient evidence of benefit to recommend it at present. Future trials will need to be better designed than this one. Connolly, S. J., Sharma, M., Cohen, A. T. et al., … Read more
BP control in stroke
The Stroke management page has been updated with some revised recommendations for BP management following the publication of the following paper.Li, G., Lin, Y., Yang, J., et al., (2024). Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke. N Engl J Med, 390(20), 1862-1872. https://doi.org/10.1056/NEJMoa2314741
Weakness image improvements
Multiple images in the Weakness section have been reformatted to improve quality and load speed.
Headache image improvements
Multiple images in the Headache section have been reformatted to improve quality and load speed.
Stroke image improvements
Multiple images in the Stroke section have been reformatted to improve quality and load speed.
Neurological assessment image improvements
Multiple images in the Neurological assessment section have been reformatted to improve quality and load speed.