Pre PCI beta blockers

The Management of acute coronary syndromes page has been updated with additional information about the role of pre-PCI beta blockers. Roolvink, V, Ibanez, B, Ottervanger, JP, et al. Early Administration of intravenous Beta blockers in patients with ST-elevation myocardial infarction before primary PCI. Journal of the American College of Cardiology 2016.

Myoglobin in ACS

The Other cardiac biomarkers page has been updated with additional information about the role of myoglobin in excluding ACS in low risk patients. Meek, R, Braitberg, G, Cullen, L, et al. Outcome at 30 days for low-risk chest pain patients assessed using an accelerated diagnostic pathway in the emergency department. Emerg Med Australas 2016.

Ulcer size increases rebleeding risk

The Upper GI haemorrhage page has been updated and the size of the ulcer added as a risk factor for rebleeding. Camus, M, Jensen, DM, Kovacs, TO, et al. Independent risk factors of 30-day outcomes in 1264 patients with peptic ulcer bleeding in the USA: large ulcers do worse. Alimentary Pharmacology & Therapeutics 2016:n/a-n/a. . … Read more

Early second shock in in-hospital cardiac arrest

The Advanced cardiac life support page has been revised to increase the emphasis on the utility of an early second shock in in-hospital cardiac arrest. Bradley, SM, Liu, W, Chan, PS, et al. Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. BMJ 2016:i1653.

Scurvy

A new segment on Scurvy has been added to the Anaemia page. Even though scurvy also has skin, bone and CNS features the reason it has been put there is that anaemia is the most consistent finding in scurvy.

Chronic pain

The Chronic pain page has been updated following the publication of the CDC Guidelines for the use of opioids in chronic pain. Dowell, D, Haegerich, TM, Chou, R. CDC Guideline for Prescribing Opioids for Chronic Pain-United States, 2016. JAMA 2016 .  

Mesenteric ischaemia

The Mesenteric ischaemia page has been extensively revised following the publication of the following review article. Campion, EW, Clair, DG, Beach, JM. Mesenteric Ischemia. New England Journal of Medicine 2016;374(10):959-68.