tPA for stroke between 3-4.5 hours

Some additional information about the role of tPA in patients selected without advanced imaging (e.g. CT perfusion, DWI MRI) between 3-4.5 hours has been added to the Thrombolytic therapy in stroke page following the BMJ article published today that does not support the evidence for the use of tPA for this time window.

EXTEND 1A Stroke trial

The Stroke Management, Thrombolytic therapy in stroke and Investigation of stroke pages have been updated following publication of the EXTEND 1A trial in the NEJM today showing substantial benefit for endovascular intervention following tPA in patients selected by CT perfusion to be likely to have benefit.