Dextromethorphan/quinidine for agitated dementia

The Altered mental state page has been updated with information about the use of dextromethorphan/quinidine for behavioural control. Cummings, JL, Lyketsos, CG, Peskind, ER, et al. Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA 2015;314(12):1242-54. http://www.ncbi.nlm.nih.gov/pubmed/26393847.

Assessment of vision in young children

The Assessment of vision page has been updated with some additional information about the assessment of vision in young children following a recent BMJ article on the subject. Blaikie, AJ, Dutton, GN. How to assess eyes and vision in infants and preschool children. BMJ 2015;350:h1716. 

Aneurysmal SAH epidemiology

The Subarachnoid haemorrhage page has been updated with some additional details about the epidemiology and natural history of intracerebral aneurysms following a recent guideline published on the topic. Thompson BG, Brown RD, Jr., Amin-Hanjani S, et al. Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms: A Guideline for Healthcare Professionals From the American … Read more

tPA for stroke between 3-4.5 hours

Some additional information about the role of tPA in patients selected without advanced imaging (e.g. CT perfusion, DWI MRI) between 3-4.5 hours has been added to the Thrombolytic therapy in stroke page following the BMJ article published today that does not support the evidence for the use of tPA for this time window.