GHB

The section on GHB in the Other sedative hypnotics page has been revised and updated.

Delayed phase anaphylaxis

The Anaphylaxis page has been updated to better emphasise the rarity of delayed phase anaphylaxis in ED patients and to avoid routine long periods of observation for patients with anaphylaxis otherwise improved with therapy.van der Zwet, K. V. M., van Vossen-Treur, D., Venema, E., Guillen, S., & Moore-van Leest, E. J. (2022). Biphasic Allergic Reactions … Read more

Clot retrieval for basilar artery occlusion

The Stroke management page has been updated with additional information about the benefit of clot retrieval for basilar artery occlusion.Tao, C., Nogueira, R. G., Zhu, Y., Sun, J., Han, H., Yuan, G., Wen, C., Zhou, P., Chen, W., Zeng, G., Li, Y., Ma, Z., Yu, C., Su, J., Zhou, Z., Chen, Z., Liao, G., Sun, … Read more

PE and heart rate

Various pages have been updated to re-emphasise that heart rate is only > 100 bpm in about 40% of patients, so it is not a good screening variable. Increasing heart rate, however, is a good indicator of poorer prognosis.Yamashita, Y., Morimoto, T., Takase, T., et al., (2023). Impact of Heart Rate at Diagnosis on Clinical … Read more

Nitrates are not contra-indicated in RV infarction

The Management of ACS page has been updated to more clearly emphasise that nitrates are not contra-indicated in RV infarction, but some caution may be required due to potential hypotension.Wilkinson-Stokes, M., Betson, J., & Sawyer, S. (2022). Adverse events from nitrate administration during right ventricular myocardial infarction: a systematic review and meta-analysis. Emerg Med J. … Read more